Author: Prof. Dott. Celestino Sardu

A Geriatric Assessment Score Predicting 1-Year Mortality and Functional Decline After TAVR: The GASS-TAVR Study Abstract Background. Many older patients treated with transcatheter aortic valve replacement (TAVR) do not obtain a meaningful clinical benefit one year after the procedure, so better tools for risk stratification are needed. Objectives. The investigators…

Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients Abstract Background. Cardiac resynchronization therapy (CRT) failure leads to adverse remodeling and poor outcomes. Objectives. The purpose of this study was to evaluate vericiguat effects on outcomes, mitochondrial function, and inflammation/oxidative stress in CRT nonresponders at…

Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study Abstract BackgroundEndothelial dysfunction (ED) is a negative prognostic factor for patients with heart failure (HF) who are treated with cardiac resynchronization therapy (CRT). ED could lead to CRT non-responders by increasing endothelin-1 (ET-1) expression and inflammatory/oxidative…