Author: Prof. Dott. Celestino Sardu

Detection and Proinflammatory Effects of BTEX within the Human Atherosclerotic Plaque Abstract Background. Circulating levels of benzene, toluene, xylene (the sum of the ortho-, meta- and para- isomers) and ethylbenzene, collectively known as BTEX, have been linked to a higher incidence of cardiovascular disease, but the mechanisms involved were unknown.…

Cardioprotective mechanism of ω-3 fatty acid icosapent ethyl (IPE) in cardiomyocytes: role in high glucose and shear stress-induced mechano-transduction dysregulation Abstract Background. Omega-3 fatty acids are long-chain fatty acids credited with cardioprotective properties through lipid lowering, anti-inflammatory and membrane-stabilising actions. This work explored the molecular basis of the cardioprotection offered…

In vitro evidence and integrative bioinformatics identify the SGLT2-PPARγ axis as a target against polyethylene microplastic-driven metabolic reprogramming in colorectal cancer cells Abstract Background. Microplastics represent a growing burden for human health and chronic exposure has been linked to inflammation, metabolic derangement and carcinogenesis. These particles can be taken up…

Environmental Pollutant-Induced Cardiopathogenesis Through Immune Dysfunction: The Emerging Role of Micro- and Nanoplastics Abstract Background. Exposure to environmental pollutants is now regarded as a relevant driver of cardiovascular disease. Beyond their direct toxicity, these agents disturb immune homeostasis and in this way favour endothelial dysfunction, plaque formation, arrhythmias and impaired…

A Geriatric Assessment Score Predicting 1-Year Mortality and Functional Decline After TAVR: The GASS-TAVR Study Abstract Background. Many older patients treated with transcatheter aortic valve replacement (TAVR) do not obtain a meaningful clinical benefit one year after the procedure, so better tools for risk stratification are needed. Objectives. The investigators…