Category: Pubblicazioni Scientifiche

A Geriatric Assessment Score Predicting 1-Year Mortality and Functional Decline After TAVR: The GASS-TAVR Study Abstract Background. Many older patients treated with transcatheter aortic valve replacement (TAVR) do not obtain a meaningful clinical benefit one year after the procedure, so better tools for risk stratification are needed. Objectives. The investigators…

Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients Abstract Background. Cardiac resynchronization therapy (CRT) failure leads to adverse remodeling and poor outcomes. Objectives. The purpose of this study was to evaluate vericiguat effects on outcomes, mitochondrial function, and inflammation/oxidative stress in CRT nonresponders at…

Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study Abstract BackgroundEndothelial dysfunction (ED) is a negative prognostic factor for patients with heart failure (HF) who are treated with cardiac resynchronization therapy (CRT). ED could lead to CRT non-responders by increasing endothelin-1 (ET-1) expression and inflammatory/oxidative…

Vericiguat per la disfunzione endoteliale e la risposta alla CRT nei non-responder: lo studio osservazionale prospettico VERCET Abstract Contesto: La disfunzione endoteliale (ED) è un fattore prognostico negativo per i pazienti affetti da scompenso cardiaco (HF) trattati con la terapia di resincronizzazione cardiaca (CRT). La disfunzione endoteliale potrebbe portare alla…

Effects of combination therapy with SGLT2 inhibitors and GLP-1 receptor agonists on CRT response and clinical outcomes in in type 2 diabetes mellitus patients receiving chronic anti-diabetic medications: A multicenter observational study Abstract Background: Type-2-diabetes-mellitus (T2DM) impairs outcomes in patients undergoing cardiac-resynchronization-therapy-with-defibrillator (CRTd).While both sodium-glucose co-transporter 2 inhibitors (SGLT2i) and…

Effects of Combined Therapy with SGLT2i and GLP-1RAs on Atrial Fibrillation Recurrence After Catheter Ablation in Diabetic Cohorts: One-Year Outcomes from Continuous Monitoring Abstract To evaluate the effect of sodium–glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1RAs), and their combination on atrial fibrillation (AF) recurrence after catheter ablation in…

Effects of combination therapy with SGLT2 inhibitors and GLP-1 receptor agonists on CRT response and clinical outcomes in in type 2 diabetes mellitus patients receiving chronic anti-diabetic medications: A multicenter observational study Abstract Type-2-diabetes-mellitus (T2DM) impairs outcomes in patients undergoing cardiac-resynchronization-therapy-with-defibrillator (CRTd). While both sodium-glucose co-transporter 2 inhibitors (SGLT2i) and…

Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: The CARVAS study Abstract Study hypothesis.Cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients.Background.VVS recurrence might be due to alterations of autonomic system…

Angiotensin receptor/Neprilysin inhibitor effects in CRTd non-responders: From epigenetic to clinical beside Abstract Objectives. We evaluated whether Angiotensin receptor/Neprilysin inhibitors (ARNI) reduce heart failure (HF) hospitalizations and deaths in cardiac resynchronization therapy with defibrillator (CRTd) non-responders patients at 12 months of follow-up, modulating microRNAs (miRs) implied in adverse cardiac remodeling.…